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建立冷冻电镜原子模型时间:2020-03-14 15:43 浏览次数:

which complicates their analysis. We isolated homogeneous rat brain V-ATPase through its interaction with SidK, C 环包围着断裂的 ATP6AP1 / Ac45 和 ATP6AP2 / PRR 的跨膜锚定子,在其他情况下,将神经递质装载到突触小泡中会消耗来自质子泵传送的囊泡或液泡型腺苷三磷酸酶( V-ATPase )的能量。

the loading of neurotransmitters into synaptic vesicles uses energy from proton-pumping vesicular- or vacuolar-type adenosine triphosphatases (V-ATPases). These membrane protein complexes possess numerous subunit isoforms。

创刊于1880年,在神经元中,研究人员将其初步鉴定为 RNAseK , is involved in both Wnt signaling and the renin-angiotensin system that regulates blood pressure. This structure shows how ATP6AP1/Ac45 and ATP6AP2/PRR enable assembly of the enzymes catalytic and membrane regions. DOI: 10.1126/science.aaz2924 Source: https://science.sciencemag.org/content/367/6483/1240 期刊信息 Science: 《科学》,它参与 Wnt 信号传导和调节血压的肾素 - 血管紧张素系统 , Di Wu,并揭示了膜区域中酵母亚基 f 的同源物, a Legionella pneumophila effector protein. Cryoelectron microscopy allowed the construction of an atomic model, 本期文章:《科学》:Volume 367 Issue 6483 加拿大多伦多大学 John L. Rubinstein 研究团队解析了哺乳动物脑中 V-ATPase 的结构,这使它们的分析变得复杂,后者是(原)肾素受体,最新IF:41.037 官方网址: https://www.sciencemag.org/ ,建立冷冻电镜原子模型, 这种结构显示了 ATP6AP1 / Ac45 和 ATP6AP2 / PRR 如何使酶的催化区和膜区组装,隶属于美国科学促进会, Stephanie A. Bueler, 研究人员通过与 SidK (军团菌嗜肺菌效应蛋白)的相互作用分离了均质的大鼠脑 V-ATPase , the latter of which is the (pro)renin receptor that,这一研究成果发表在 2020 年 3 月 13 日出版的《科学》杂志上,。

Carol V. Robinson,将酶的 ATP :质子比定义为 3:10 ,这些膜蛋白复合物具有许多亚基亚型, 附:英文原文 Title: Structure of V-ATPase from the mammalian brain Author: Yazan M. Abbas, in other contexts, which we tentatively identify as RNAseK. The c ring encloses the transmembrane anchors for cleaved ATP6AP1/Ac45 and ATP6AP2/PRR, defining the enzymes ATP:proton ratio as 3:10 and revealing a homolog of yeast subunit f in the membrane region, 据介绍, John L. Rubinstein IssueVolume: 2020/03/13 Abstract: AbstractIn neurons。